Université de Rouen, IRCOF, 76821 Mont-Saint-Aignan Cedex, France.
J Mass Spectrom. 2010 Oct;45(10):1121-9. doi: 10.1002/jms.1790.
Metopimazine (MPZ) is a phenothiazine derivative used to prevent emesis during chemotherapy where few structural analysis of the aforementioned compound have been described in the literature. Thus, this work reports, for the first time, the detailed study of fragmentation pathways of MPZ and its metabolite (AMPZ) using electrospray ionization (EI) with multistage mass spectrometry (ESI-MS(n)) in positive-ion mode. The structures of 21 product ions were identified and their accurate masses were determined using high resolution mass spectrometry (HRMS) experiments. Characteristic product ions of these two phenothiazine derivatives are more particularly displayed along with differences between their relative abundances and their structures checked by H/D exchange experiments.
甲哌吩嗪（MPZ）是一种吩噻嗪衍生物，用于预防化疗时的呕吐，而文献中很少有对上述化合物的结构分析。因此，本工作首次报道了采用电喷雾电离（EI）与多级质谱（ESI-MS(n)）联用在正离子模式下对 MPZ 及其代谢物（AMPZ）的断裂途径进行的详细研究。通过高分辨质谱（HRMS）实验确定了 21 个产物离子的结构，并测定了它们的精确质量。这些两种吩噻嗪衍生物的特征产物离子更为特别地显示出来，同时还比较了它们的相对丰度差异及其结构，这些结构通过氘代交换实验进行了验证。
