猫肉瘤病毒假型包含一种具有猫肿瘤病毒相关细胞膜抗原（FOCMA）活性的85,000道尔顿蛋白质。
Pseudotypes of feline sarcoma virus contain an 85,000-dalton protein with feline oncornavirus-associated cell membrane antigen (FOCMA) activity.
作者信息
Sherr C J, Sen A, Todaro G J, Sliski A, Essex M
出版信息
Proc Natl Acad Sci U S A. 1978 Mar;75(3):1505-9. doi: 10.1073/pnas.75.3.1505.
Abstract
Feline sarcoma virus (FeSV) rescued from transformed nonproducer mink or rat cells contains two FeSV-specific antigens (p15 and p12), and the feline oncornavirus-associated cell membrane antigen (FOCMA). All three antigens are helper virus-independent and are encoded by the FeSV genome, FOCMA, p15, and p12 antigens cochromatograph as phosphorylated molecules of 85,000 molecular weight (pp85), adsorb to immunoadsorbant columns prepared with antibodies to feline leukemia virus (FeLV), and are precipitated with antisera to FeLV or FOCMA. Antibodies to FOCMA can be adsorbed with fractions containing pp85 but not with FeLV proteins, including p15 and p12. Thus, a virus-coded tumor antigen which immunizes cats against tumors induced by feline type C viruses is packaged in FeSV particles and is linked to viral structural protein.
摘要
从转化的非生产性貂或大鼠细胞中拯救出的猫肉瘤病毒（FeSV）含有两种FeSV特异性抗原（p15和p12）以及猫肿瘤病毒相关细胞膜抗原（FOCMA）。这三种抗原均不依赖辅助病毒，由FeSV基因组编码，FOCMA、p15和p12抗原作为分子量为85,000的磷酸化分子（pp85）共层析，吸附到用抗猫白血病病毒（FeLV）抗体制备的免疫吸附柱上，并用抗FeLV或FOCMA抗血清沉淀。抗FOCMA抗体可被含pp85的组分吸附，但不能被包括p15和p12在内的FeLV蛋白吸附。因此，一种能使猫对C型猫病毒诱导的肿瘤产生免疫的病毒编码肿瘤抗原被包装在FeSV颗粒中，并与病毒结构蛋白相连。
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Pseudotypes of feline sarcoma virus contain an 85,000-dalton protein with feline oncornavirus-associated cell membrane antigen (FOCMA) activity.猫肉瘤病毒假型包含一种具有猫肿瘤病毒相关细胞膜抗原（FOCMA）活性的85,000道尔顿蛋白质。
Proc Natl Acad Sci U S A. 1978 Mar;75(3):1505-9. doi: 10.1073/pnas.75.3.1505.
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