Jashari R, Goffin Y, Van Hoeck B, Vanderkelen A, du Verger A, Fan Y, Holovska V, Fagu A, Brahy O
European Homograft Bank (EHB), International Association, c/o Military Hospital Queen Astrid, Brussels, Belgium.
Acta Chir Belg. 2010 May-Jun;110(3):280-90. doi: 10.1080/00015458.2010.11680618.
European Homograft Bank (EHB) has been selecting, preparing, storing and distributing the cryopreserved allograft valves in Belgium and some other European Countries since 1989. It was established in 1988 by a pathologist and the cardiac and vascular surgeons from Belgian and other European centres as an inter-university, international nonprofit association. Due to its neutral behavior and very high quality criteria, European Homograft Bank became one of the prominent heart valve banks in Europe and wider. It collaborates with the transplant coordination in donor selection as well as with the huge network of the implanting surgeons in Belgium and other European Countries. The EHB responsible discusses with the implanting surgeon the allograft selection on basis of the indication and the patients state of emergency. A total of 8.911 donor heart valves have been evaluated in EHB during the last 20 years. After selection, 5.258 allograft valves (1.996 aortic, 3.189 pulmonary and 73 mitral) were cryopreserved and stored in vapors of liquid nitrogen between 6 weeks and 5 years. A total of 4.516 allograft valves (1.391 aortic, 2.620 pulmonary and 48 mitral) were implanted in the left or right ventricular outflow tract for replacement of the diseased aortic or pulmonary valve and for mitral or tricuspid valve replacement or repair. In 1.380 cases the allograft valves were used for right ventricular outflow tract reconstruction as part of the Ross- procedure, whereas in 668 cases the allograft valve served for replacement of the aortic valve for endocarditis. The most important indications for use of cryopreserved allograft valves were: important cardiac and valve malformation in children, female patients of child-bearing age with diseased cardiac valves, cases with contra-indication for anti-coagulation and the patients with severe endocarditis with septal or annular abscesses. Although the number of the donation increased by year, the available allograft valves in stock are still insufficient to respond to all the surgeons' request for different indications.
自1989年以来，欧洲同种异体移植库（EHB）一直在比利时和其他一些欧洲国家挑选、制备、储存和分发冷冻保存的同种异体移植瓣膜。它于1988年由一位病理学家以及来自比利时和其他欧洲中心的心脏和血管外科医生成立，是一个大学间的国际非营利协会。由于其中立的行为和非常高的质量标准，欧洲同种异体移植库成为欧洲及更广泛地区著名的心脏瓣膜库之一。它在供体选择方面与移植协调部门合作，并与比利时和其他欧洲国家庞大的植入外科医生网络合作。EHB的负责人会与植入外科医生根据适应症和患者的紧急情况讨论同种异体移植瓣膜的选择。在过去20年里，EHB共评估了8911个供体心脏瓣膜。经过挑选，5258个同种异体移植瓣膜（1996个主动脉瓣、3189个肺动脉瓣和73个二尖瓣）被冷冻保存，并在6周至5年的时间里储存在液氮蒸汽中。共有4516个同种异体移植瓣膜（1391个主动脉瓣、2620个肺动脉瓣和48个二尖瓣）被植入左或右心室流出道，用于置换病变的主动脉瓣或肺动脉瓣，以及进行二尖瓣或三尖瓣置换或修复。在1380例病例中，同种异体移植瓣膜用于右心室流出道重建，作为罗斯手术的一部分，而在668例病例中，同种异体移植瓣膜用于置换感染性心内膜炎的主动脉瓣。使用冷冻保存同种异体移植瓣膜的最重要适应症包括：儿童重要的心脏和瓣膜畸形、患有病变心脏瓣膜的育龄女性患者、有抗凝禁忌症的病例以及患有严重心内膜炎并伴有间隔或瓣环脓肿的患者。尽管捐赠数量逐年增加，但库存中可用的同种异体移植瓣膜仍然不足以满足所有外科医生针对不同适应症的需求。
