Vasilevskaia L S, Stan E Ia, Chernikov M P, Shlygin G K
Vopr Pitan. 1977 Jul-Aug(4):21-4.
Tests staged on dogs demonstrated the action of GMP to differ depending upon the nature of the gastric secretion stimulant actually used. The inhibition of the gastric juice secretion occurring against the background of multiple introduction of histamine or gastrin tetrapeptide amide was quite spectacular: the secretion dropped down to zero and the action was more prolonged than following administration of pentagastrin with which the secretion was not inhibited to such a sharp degree and the effect of GMP was less protracted. The mechanism of the GMP action of the gastric secretion and the causes of described differences require further investigations.
在狗身上进行的实验表明，胃动素（GMP）的作用会因实际使用的胃液分泌刺激物的性质不同而有所差异。在多次注射组胺或胃泌素四肽酰胺的背景下，胃液分泌受到的抑制相当显著：分泌量降至零，且这种作用比注射五肽胃泌素后的作用持续时间更长，注射五肽胃泌素时分泌并未受到如此显著的抑制，胃动素的作用持续时间也较短。胃动素对胃液分泌的作用机制以及上述差异的原因需要进一步研究。
