Vaidya S, Mamlok R, Daeschner C W, Williams J, Ruth J, Goldblum R M
Department of Pathology, University of Texas Medical Branch, Galveston 77550.
Am J Pediatr Hematol Oncol. 1991 Summer;13(2):172-5. doi: 10.1097/00043426-199122000-00013.
Simultaneous engraftment of maternal T cells and T cells from unrelated transfusion donor in an infant with severe combined immunodeficiency disease (SCID) was identified by HLA typing blood lymphocytes of the patient, her triplet siblings, parents, and the platelet donor from whom the patient received nonirradiated platelet transfusion. T cell grafts from both the mother and platelet donor were stable for several months, but the graft-versus-host reactions (GvHR) remained mild and immune function was deficient. We hypothesize that immunosuppressive effects of a maternal-fetal GvHR may have modified the expected lethal GvHR from platelet donor's T cells.
通过对一名患有严重联合免疫缺陷病（SCID）婴儿及其三胞胎兄弟姐妹、父母以及该患者接受非辐照血小板输注的血小板供者的血液淋巴细胞进行HLA分型，发现该婴儿同时植入了母体T细胞和来自无关输血供者的T细胞。来自母亲和血小板供者的T细胞移植物在数月内保持稳定，但移植物抗宿主反应（GvHR）仍然轻微，免疫功能存在缺陷。我们推测，母胎GvHR的免疫抑制作用可能改变了来自血小板供者T细胞预期的致死性GvHR。
