Okuma T, Honda H
Psychopharmacology (Berl). 1978 Apr 28;57(2):127-32. doi: 10.1007/BF00426876.
Experimental sleep disturbance (model insomnia) was produced by intermittent white noise and the administration of 10 mg of methylphenidate (MPD). The effects of flurazepam (FZP) 15 mg and triazolam (TZM) 0.25 mg on these models was investigated. All night sleep polygraphy was performed on 8 normal male subjects under each of the following 9 conditions: baseline, TZM 0.25 mg, FZP 15 mg, white noise alone, noise and TZM, noise and FZP, MPD alone, MPD and TZM, and MPD and FZP. A reduction in total sleep time and stage were (S-REM) and an increase in the wakening stage were observed with both noise and MPD. Stage 4 sleep was reduced only by MPD. Administration of TZM or EZP did not cause any significant change in sleep parameters. These drugs in combination with noise or MPD resulted in almost complete recovery of the sleep disturbance induced by noise or MPD, except for a reduction in S-REM. These results indicate that model insomnia, particularly MPD insomnia, will assist in the evaluation of hypnotic drugs.
通过间歇性白噪声和给予10毫克哌甲酯（MPD）产生实验性睡眠障碍（模型失眠）。研究了15毫克氟西泮（FZP）和0.25毫克三唑仑（TZM）对这些模型的影响。在以下9种条件下，对8名正常男性受试者进行了整夜睡眠多导记录：基线、0.25毫克TZM、15毫克FZP、单独白噪声、噪声加TZM、噪声加FZP、单独MPD、MPD加TZM以及MPD加FZP。噪声和MPD均导致总睡眠时间和睡眠阶段（快速眼动睡眠期，S-REM）减少，觉醒阶段增加。仅MPD使第4阶段睡眠减少。给予TZM或FZP未引起睡眠参数的任何显著变化。这些药物与噪声或MPD联合使用，除了快速眼动睡眠期减少外，几乎完全恢复了由噪声或MPD引起的睡眠障碍。这些结果表明，模型失眠，尤其是MPD失眠，将有助于评估催眠药物。
