Takita M, Matsumoto S, Noguchi H, Shimoda M, Chujo D, Itoh T, Sugimoto K, Tamura Y, Olsen G S, Naziruddin B, Onaca N, Levy M F
Baylor All Saints, Islet Cell Laboratory, Fort Worth, Dallas, Texas 76104, USA.
Transplant Proc. 2010 Jul-Aug;42(6):2065-7. doi: 10.1016/j.transproceed.2010.05.102.
Simple monitoring of engrafted islet function is important for follow-up of recipients after islet transplantation. We previously developed a simple assessment tool for islet graft function; the secretory unit of islet transplant objects (SUITO) index. The aim of this study was to clarify the relationship between the SUITO index and the outcomes of intravenous glucose tolerance tests (IVGTT).
Fifteen series of blood samples from 6 islet recipients were collected before 3, 5, 10, 20, and 30 minutes after injection of 0.5 g/kg 50% dextrose. The SUITO index was calculated using plasma C-peptide and glucose level at fasting baseline. Samples were divided into the following 3 groups; low-SUITO (SUITO index <10; n = 3); middle-SUITO (SUITO index > or =10 to <26; n = 4); and high-SUITO (SUITO index > or =26; n = 8).
A threshold SUITO index of 26 showed good sensitivity (85.7%) and specificity (75.0%) to predict a blood glucose level of >10 mmol/L at 30 minutes. Blood glucose levels in the low-SUITO group were significantly higher than among the other 2 groups at baseline and 10, 20 and 30 minutes (P < .05). Glucose-level areas under the receiver-operating characteristic curve during IVGTT in the low-SUITO group were also significantly larger than among the other 2 groups (P < .05).
The SUITO index, using only a fasting blood sample, predicted IVGTT outcomes.
对移植胰岛功能进行简单监测对于胰岛移植受者的随访很重要。我们之前开发了一种用于评估胰岛移植功能的简单工具；胰岛移植对象分泌单位（SUITO）指数。本研究的目的是阐明SUITO指数与静脉葡萄糖耐量试验（IVGTT）结果之间的关系。
收集6名胰岛移植受者在注射0.5g/kg 50%葡萄糖后3、5、10、20和30分钟前的15组血样。SUITO指数通过空腹基线时的血浆C肽和葡萄糖水平计算得出。样本分为以下3组；低SUITO组（SUITO指数<10；n = 3）；中SUITO组（SUITO指数≥10至<26；n = 4）；高SUITO组（SUITO指数≥26；n = 8）。
SUITO指数阈值为26时，预测30分钟时血糖水平>10mmol/L具有良好的敏感性（85.7%）和特异性（75.0%）。低SUITO组在基线、10、20和30分钟时的血糖水平显著高于其他两组（P <.05）。低SUITO组IVGTT期间受试者工作特征曲线下的葡萄糖水平面积也显著大于其他两组（P <.05）。
仅使用空腹血样的SUITO指数可预测IVGTT结果。
