早发性帕金森病的 TCS。

TCS in monogenic forms of Parkinson's disease.

机构信息

Department of Neurodegeneration, Hertie Institute of Clinical Brain Research and German Center of Neurodegenerative Diseases (DZNE), Tübingen, Germany.

出版信息

Int Rev Neurobiol. 2010;90:157-64. doi: 10.1016/S0074-7742(10)90011-1.

DOI:10.1016/S0074-7742(10)90011-1

PMID:20692500

Abstract

During the last decade, mutations in a growing number of genes have been found to cause monogenic forms of Parkinson's disease (PD). Moreover, many studies shed light on their contribution to sporadic variants of PD. Since hyperechogenicity of the substantia nigra (SN) represents a characteristic hallmark of sporadic PD questions arise concerning the echo pattern of monogenic forms of this disorder on TCS.

摘要

在过去的十年中，越来越多的基因突变被发现可导致单基因形式的帕金森病（PD）。此外，许多研究揭示了它们对散发性 PD 变异体的贡献。由于黑质（SN）的高回声是散发性 PD 的一个特征性标志，因此关于 TCS 中单基因形式这种疾病的回声模式的问题出现了。