Roy T A, Saladdin K A, Mackerer C R
Environmental and Health Sciences Laboratory, Mobil Oil Corporation, Princeton, New Jersey, USA.
Toxicol In Vitro. 1994 Aug;8(4):797-8. doi: 10.1016/0887-2333(94)90070-1.
89 petroleum products were tested in the EYTEX in vitro assay and the results were compared with data from Draize tests on the same materials. All 26 chemicals assessed as irritant in the Draize test were classified as irritant by the EYTEX assay; 61 of the 63 non-irritants were correctly classified by the in vitro assay. The correlation between the results from the EYTEX system and the Draize data was 89%, and the predictive value of the EYTEX system (percentage of EYTEX irritants that are true irritants) was 93%. When the same chemicals were tested in another laboratory, the coefficient of determination for the comparison of the EYTEX scores from the two laboratories was R(2) = 0.86. The results demonstrate the reliability and interpretability of the EYTEX assay carried out in our laboratory and therefore the viability, if not the validity, of this in vitro method as a screening test for the Draize assay.
在EYTEX体外试验中对89种石油产品进行了测试，并将结果与对相同材料进行的Draize试验数据进行了比较。在Draize试验中被评估为刺激性的所有26种化学品在EYTEX试验中都被归类为刺激性；63种非刺激性物质中的61种通过体外试验被正确分类。EYTEX系统结果与Draize数据之间的相关性为89%，EYTEX系统的预测值（EYTEX刺激性物质中真正刺激性物质的百分比）为93%。当在另一个实验室对相同化学品进行测试时，两个实验室的EYTEX评分比较的决定系数为R(2)=0.86。结果证明了在我们实验室进行的EYTEX试验的可靠性和可解释性，因此这种体外方法作为Draize试验的筛选试验即使没有有效性，也具有可行性。
