Department of Medical Oncology, Prince of Wales Hospital, High Street, Randwick, NSW Australia.
Oncologist. 2010;15(8):830-5. doi: 10.1634/theoncologist.2010-0074. Epub 2010 Aug 5.
The use of selective internal radiation therapy (SIRT) with SIR-Spheres(R) (Sirtex, Sydney, Australia) is increasingly recognized as a potential therapeutic modality of primary and secondary malignant liver tumors. A number of treatment-related complications have been described despite technical expertise and detailed pretreatment investigations to assess suitability. We describe a case of gastric ulceration from nontargeted deposition of SIR-spheres(R) in the gastric mucosa with life-threatening consequences. This case highlights the need for careful screening and appropriate patient selection, and the need to recognize ulceration from SIRT as a potential complication of treatment. The characteristic endoscopic, radiologic, and histopathologic findings are illustrated and recommendations are reviewed with regard to the current literature.
使用选择性内部放射治疗（SIRT）联合 SIR-Spheres（®）（Sirtex，澳大利亚悉尼）越来越被认为是原发性和继发性恶性肝肿瘤的潜在治疗方法。尽管有技术专长和详细的预处理研究来评估适宜性，但仍描述了一些与治疗相关的并发症。我们描述了一例由于 SIR-spheres（®）在胃黏膜中的非靶向沉积导致的胃溃 疡病例，该病例具有威胁生命的后果。该病例强调了需要仔细筛选和适当的患者选择，以及需要认识到 SIRT 引起的溃疡是治疗的潜在并发症。本文展示了其特征性的内镜、放射学和组织病理学表现，并结合现有文献对治疗建议进行了回顾。
