Department of Dermatology and Skin Science and Child and Family Research Institute, University of British Columbia, Canada.
Lupus. 2010 Aug;19(9):1029-35. doi: 10.1177/0961203310370045.
Cutaneous lupus erythematosus (CLE) may present as a clinically heterogeneous group of lupus-specific skin lesions that have common histopathological findings. Determination of the immunopathological sequence of events in this group of disorders has been challenging for dermatologists and immunologists but is vital for therapeutic targeting. We review animal models in which different aspects of immune alteration in CLE have been addressed. The MRL/lpr mouse develops spontaneous skin disease with some features of CLE. Study of this strain and related gene-manipulated strains has revealed roles for multiple cytokines, including interleukin (IL)-6, IL-18, and IL-21, in disease pathogenesis. A role for the growth factor colony stimulating factor 1 and the inflammatory protein high-mobility group box 1 has also been suggested. We discuss potential novel treatment options suggested by these models.
皮肤狼疮红斑（CLE）可能表现为一组具有共同组织病理学发现的具有狼疮特异性皮肤损害的临床表现多样的疾病。对于皮肤科医生和免疫学家来说，确定这组疾病的免疫病理序列事件一直具有挑战性，但对于治疗靶点至关重要。我们回顾了在 CLE 中不同方面的免疫改变已经得到解决的动物模型。MRL/lpr 小鼠自发发生具有 CLE 某些特征的皮肤疾病。对该品系和相关基因修饰品系的研究揭示了多种细胞因子（包括白细胞介素（IL）-6、IL-18 和 IL-21）在疾病发病机制中的作用。生长因子集落刺激因子 1 和炎症蛋白高迁移率族蛋白 1 的作用也被提出。我们讨论了这些模型提出的潜在新的治疗选择。
