通过增加生长因子的浓度来拮抗转化生长因子-β对小鼠骨髓细胞体外集落形成的抑制作用。
Antagonism of the inhibitory effects of transforming growth factor-beta on colony formation of mouse bone marrow cells in vitro by increasing concentrations of growth factors.
作者信息
Bradley T R, Millar J L, Bertoncello I, Powles R L
机构信息
Institute of Cancer Research, Sutton, Surrey, United Kingdom.
出版信息
Ann N Y Acad Sci. 1991;628:52-8. doi: 10.1111/j.1749-6632.1991.tb17222.x.
Low concentrations of TGF-beta inhibited the clonal proliferation of three different preparations of mouse bone marrow progenitor cells in vitro. Normal marrow cells responsive to CSF-1; two-day post-fluorouracil cells responsive to CSF-1 plus IL-3 and IL-1 alpha; and regenerating seven-day post-fluorouracil cells responsive to CSF-1 plus IL-3, IL-1 alpha and IL-6 were all severely inhibited by TGF-beta 1; and the inhibitory effects were antagonized by increasing the concentrations of the relevant growth factors.
低浓度的转化生长因子-β（TGF-β）在体外抑制了三种不同制备的小鼠骨髓祖细胞的克隆增殖。对集落刺激因子-1（CSF-1）有反应的正常骨髓细胞；对CSF-1加白细胞介素-3（IL-3）和白细胞介素-1α（IL-1α）有反应的氟尿嘧啶处理两天后的细胞；以及对CSF-1加IL-3、IL-1α和IL-6有反应的氟尿嘧啶处理七天后的再生细胞，均被TGF-β1严重抑制；并且通过增加相关生长因子的浓度可拮抗这种抑制作用。
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