Medical Physics Graduate Program, Duke University, Durham, NC 27705, USA.
Phys Med Biol. 2010 Sep 7;55(17):4977-92. doi: 10.1088/0031-9155/55/17/007. Epub 2010 Aug 6.
The objective of this paper is threefold: (1) to establish sensitivity of XRQA and EBT radiochromic films to fast neutron exposure; (2) to develop a film response to radiation dose calibration curve and (3) to investigate a two-dimensional (2D) film dosimetry technique for use in establishing an experimental setup for a radiobiological irradiation of mice and to assess the dose to the mice in this setup. The films were exposed to a 10 MeV neutron beam via the (2)H(d,n)(3)He reaction. The XRQA film response was a factor of 1.39 greater than EBT film response to the 10 MeV neutron beam when exposed to a neutron dose of 165 cGy. A film response-to-soft tissue dose calibration function was established over a range of 0-10 Gy and had a goodness of fit of 0.9926 with the calibration data. The 2D film dosimetry technique estimated the neutron dose to the mice by measuring the dose using a mouse phantom and by placing a piece of film on the exterior of the experimental mouse setup. The film results were benchmarked using Monte Carlo and aluminum (Al) foil activation measurements. The radiochromic film, Monte Carlo and Al foil dose measurements were strongly correlated, and the film within the mouse phantom agreed to better than 7% of the externally mounted films. These results demonstrated the potential application of radiochromic films for passive 2D neutron dosimetry.
(1)确定 XRQA 和 EBT 光致变色胶片对快中子暴露的灵敏度;(2)开发一种胶片响应辐射剂量校准曲线;(3)研究二维(2D)胶片剂量测定技术,用于建立小鼠放射生物学辐照的实验装置,并评估该装置中老鼠的剂量。胶片通过(2)H(d,n)(3)He 反应暴露于 10 MeV 中子束。当 XRQA 胶片在 165 cGy 的中子剂量下暴露于 10 MeV 中子束时,其响应比 EBT 胶片高 1.39 倍。建立了胶片响应-软组织剂量校准函数,范围为 0-10 Gy,校准数据拟合度为 0.9926。二维胶片剂量测定技术通过使用小鼠体模测量剂量,并将胶片放置在实验小鼠装置外部,来估计小鼠的中子剂量。使用蒙特卡罗和铝(Al)箔激活测量对胶片结果进行了基准测试。光致变色胶片、蒙特卡罗和 Al 箔剂量测量结果具有很强的相关性,并且小鼠体模内的胶片与外部安装的胶片的一致性优于 7%。这些结果表明,光致变色胶片在被动二维中子剂量测定方面具有潜在的应用。