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用于兆伏级光子束剂量测定的三维放射变色胶片堆叠剂量计的研制与特性分析

Development and characterization of a three-dimensional radiochromic film stack dosimeter for megavoltage photon beam dosimetry.

作者信息

McCaw Travis J, Micka John A, DeWerd Larry A

机构信息

Department of Medical Physics, University of Wisconsin, Madison, Wisconsin 53705.

出版信息

Med Phys. 2014 May;41(5):052104. doi: 10.1118/1.4871781.

Abstract

PURPOSE

Three-dimensional (3D) dosimeters are particularly useful for verifying the commissioning of treatment planning and delivery systems, especially with the ever-increasing implementation of complex and conformal radiotherapy techniques such as volumetric modulated arc therapy. However, currently available 3D dosimeters require extensive experience to prepare and analyze, and are subject to large measurement uncertainties. This work aims to provide a more readily implementable 3D dosimeter with the development and characterization of a radiochromic film stack dosimeter for megavoltage photon beam dosimetry.

METHODS

A film stack dosimeter was developed using Gafchromic(®) EBT2 films. The dosimeter consists of 22 films separated by 1 mm-thick spacers. A Virtual Water™ phantom was created that maintains the radial film alignment within a maximum uncertainty of 0.3 mm. The film stack dosimeter was characterized using simulations and measurements of 6 MV fields. The absorbed-dose energy dependence and orientation dependence of the film stack dosimeter were investigated using Monte Carlo simulations. The water equivalence of the dosimeter was determined by comparing percentage-depth-dose (PDD) profiles measured with the film stack dosimeter and simulated using Monte Carlo methods. Film stack dosimeter measurements were verified with thermoluminescent dosimeter (TLD) microcube measurements. The film stack dosimeter was also used to verify the delivery of an intensity-modulated radiation therapy (IMRT) procedure.

RESULTS

The absorbed-dose energy response of EBT2 film differs less than 1.5% between the calibration and film stack dosimeter geometries for a 6 MV spectrum. Over a series of beam angles ranging from normal incidence to parallel incidence, the overall variation in the response of the film stack dosimeter is within a range of 2.5%. Relative to the response to a normally incident beam, the film stack dosimeter exhibits a 1% under-response when the beam axis is parallel to the film planes. Measured and simulated PDD profiles agree within a root-mean-square difference of 1.3%. In-field film stack dosimeter and TLD measurements agree within 5%, and measurements in the field penumbra agree within 0.5 mm. Film stack dosimeter and TLD measurements have expanded (k = 2) overall measurement uncertainties of 6.2% and 5.8%, respectively. Film stack dosimeter measurements of an IMRT dose distribution have 98% agreement with the treatment planning system dose calculation, using gamma criteria of 3% and 2 mm.

CONCLUSIONS

The film stack dosimeter is capable of high-resolution, low-uncertainty 3D dose measurements, and can be readily incorporated into an existing film dosimetry program.

摘要

目的

三维(3D)剂量仪对于验证治疗计划和剂量输送系统的调试特别有用,尤其是随着容积调强弧形治疗等复杂适形放疗技术的日益广泛应用。然而,目前可用的3D剂量仪在制备和分析方面需要丰富经验,并且存在较大的测量不确定性。本研究旨在通过开发和表征用于兆伏级光子束剂量测定的放射变色胶片叠层剂量仪,提供一种更易于实施的3D剂量仪。

方法

使用Gafchromic(®) EBT2胶片开发了一种胶片叠层剂量仪。该剂量仪由22张胶片组成,中间由1毫米厚的间隔物隔开。创建了一个Virtual Water™体模,以将径向胶片对齐保持在最大0.3毫米的不确定性范围内。使用6 MV射野的模拟和测量对胶片叠层剂量仪进行了表征。使用蒙特卡罗模拟研究了胶片叠层剂量仪的吸收剂量能量依赖性和方向依赖性。通过比较用胶片叠层剂量仪测量并使用蒙特卡罗方法模拟的百分深度剂量(PDD)曲线,确定了剂量仪的水等效性。用热释光剂量仪(TLD)微立方体测量验证了胶片叠层剂量仪的测量结果。胶片叠层剂量仪还用于验证调强放射治疗(IMRT)程序的剂量输送。

结果

对于6 MV能谱,校准几何结构和胶片叠层剂量仪几何结构之间,EBT2胶片的吸收剂量能量响应差异小于1.5%。在从垂直入射到平行入射的一系列射野角度范围内,胶片叠层剂量仪响应的总体变化在2.5%范围内。相对于对垂直入射射野的响应,当射野轴与胶片平面平行时,胶片叠层剂量仪表现出1%的响应不足。测量和模拟的PDD曲线在均方根差异为1.3%的范围内一致。射野内胶片叠层剂量仪和TLD测量结果在5%以内一致,射野半影区的测量结果在0.5毫米以内一致。胶片叠层剂量仪和TLD测量的扩展(k = 2)总体测量不确定性分别为6.2%和5.8%。使用3%和2毫米的γ标准,胶片叠层剂量仪对IMRT剂量分布的测量结果与治疗计划系统剂量计算结果的一致性为98%。

结论

胶片叠层剂量仪能够进行高分辨率、低不确定性的3D剂量测量,并且可以很容易地纳入现有的胶片剂量测定程序中。

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