Takatsuka Y, Gofuku J, Katoh T, Okamura Y, Kobayakawa K, Kawahara T
Dept. of Surgery, Osaka National Hospital, Japan.
Gan To Kagaku Ryoho. 1991 Jul;18(8):1363-6.
A 56-year-old female with extensive inflammatory breast cancer was treated with intra-arterial infusion chemotherapy using a high dose of epirubicin. One cycle consisted of epirubicin; 150 mg (day 1, 4, 7) and daily administration of tamoxifen; 40 mg. After completion of 2 cycles of the regimen, both the main tumor and the extensive inflammatory skin lesion completely disappeared (CR). Hair loss, gastrointestinal disorders and leukopenia (nadir; 1,600) were the side effects encountered, but all of them were reversible. These findings suggested that dose-escalation of epirubicin was effective, and that cases with extensive skin involvement were also candidates for this modality.
一名56岁患有广泛炎性乳腺癌的女性接受了高剂量表柔比星动脉内灌注化疗。一个疗程包括表柔比星150毫克（第1、4、7天）以及每日服用他莫昔芬40毫克。在该方案的2个疗程完成后，主要肿瘤和广泛的炎性皮肤病变均完全消失（完全缓解）。出现了脱发、胃肠道紊乱和白细胞减少（最低点；1600）等副作用，但所有这些副作用都是可逆的。这些发现表明表柔比星剂量递增是有效的，并且广泛皮肤受累的病例也是这种治疗方式的适用对象。
