Borst P
The Netherlands Cancer Institute, Amsterdam.
Immunol Today. 1991 Mar;12(3):A29-33. doi: 10.1016/S0167-5699(05)80009-X.
Antigenic variation is one of the most effective strategies developed by parasites to escape immune destruction. It requires a large wardrobe of surface coats and mechanisms to exchange one coat for an unrelated one. The molecular principles of antigenic variation are now largely known in the bacterial species Borrelia and Neisseria and in the protozoa of the African trypanosome group and these three examples are discussed here by Piet Borst.
抗原变异是寄生虫为逃避免疫破坏而发展出的最有效策略之一。它需要大量的表面被膜以及将一种被膜换成另一种不相关被膜的机制。目前，在疏螺旋体属细菌和奈瑟菌属细菌以及非洲锥虫类原生动物中，抗原变异的分子原理已基本为人所知，Piet Borst在此讨论了这三个例子。
