Day K P, Marsh K
Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.
Immunol Today. 1991 Mar;12(3):A68-71. doi: 10.1016/s0167-5699(05)80020-9.
Malaria infections induce multiple humoral and cellular responses, most of which are probably not protective. This discussion of the epidemiology of acquired immunity to malaria will concentrate on two main areas: first, the relationship between parasitism and disease in endemic settings and the constraints placed on determining which responses are important in acquired protective immunity; second, the central importance of antigenic diversity in the host-parasite relationship. The emphasis throughout, unless otherwise stated, will be on the major human pathogen Plasmodium falciparum.
疟疾感染会引发多种体液和细胞反应，其中大多数可能并无保护作用。本文对疟疾获得性免疫流行病学的讨论将集中在两个主要方面：第一，在流行地区，寄生虫感染与疾病之间的关系，以及确定哪些反应在获得性保护性免疫中起重要作用时所面临的限制；第二，抗原多样性在宿主-寄生虫关系中的核心重要性。除非另有说明，本文自始至终都将重点关注主要的人类病原体恶性疟原虫。
