Department of Pediatrics, Faculty of Medicine, University of Yamanashi, Yamanashi, Japan.
Bone Marrow Transplant. 2011 Jun;46(6):835-9. doi: 10.1038/bmt.2010.191. Epub 2010 Aug 9.
Although autologous tandem hematopoietic SCT has improved the prognosis of patients with advanced high-risk neuroblastoma, the results remain unsatisfactory. In an attempt to induce the graft-versus-tumor effect, we performed autologous PBSCT followed by allogeneic cord blood transplantation in three consecutive advanced neuroblastoma cases with marked BM infiltration and high MYCN amplification. Severe acute complications did not occur in any patient and they have maintained disease-free survival for 37-60 months. This strategy appears to be feasible and effective for the treatment of extremely high-risk neuroblastoma cases.
尽管自体串联造血干细胞移植改善了晚期高危神经母细胞瘤患者的预后，但结果仍不理想。为了诱导移植物抗肿瘤效应，我们在 3 例伴有明显骨髓浸润和高 MYCN 扩增的晚期神经母细胞瘤患者中，先后进行了自体 PBSCT 和异基因脐带血移植。没有患者发生严重的急性并发症，他们均无疾病生存 37-60 个月。该策略似乎对治疗极高危神经母细胞瘤病例是可行和有效的。
