Hyytiä P, Sinclair J D
Research Laboratories, Alko Ltd., Helsinki, Finland.
Alcohol. 1991 May-Jun;8(3):229-34. doi: 10.1016/0741-8329(91)90902-9.
A method for establishing stimulus control of ethanol responding was developed. After acquisition of lever pressing for oral ethanol, rats of the high-drinking AA (Alko, Alcohol) line and of the moderate-drinking Wistar strain were subjected to alternating 20-min alcohol access periods signaled by a stimulus light, and 40-min nonaccess periods with no light. Ethanol responding during access periods progressively increased and decreased during nonaccess. These changes were faster in the AAs than the Wistars, probably related to differential reinforcement from ethanol. In a second experiment, rats responding under stimulus control were given periods of alcohol deprivation of 3, 6, 12, and 24 h, indicated by a stimulus light. Deprivations shorter than 24 h increased the first-hour intake after renewed access by the AAs, but the Wistars showed no increase until after a 24-h deprivation. The results show stimulus control of ethanol responding and demonstrate the applicability of the procedure for causing ethanol responding to occur at a time chosen by the experimenter.
开发了一种建立对乙醇反应的刺激控制的方法。在习得通过按压杠杆获取口服乙醇后，对高饮酒量的AA（阿尔科，酒精）品系大鼠和中等饮酒量的Wistar品系大鼠进行由刺激光信号指示的20分钟交替乙醇获取期，以及无光照的40分钟非获取期。获取期内的乙醇反应逐渐增加，非获取期则逐渐减少。AA品系大鼠的这些变化比Wistar品系大鼠更快，这可能与乙醇的差异强化有关。在第二个实验中，对在刺激控制下做出反应的大鼠进行3、6、12和24小时的酒精剥夺期，由刺激光指示。短于24小时的剥夺增加了AA品系大鼠重新获取乙醇后第一小时的摄入量，但Wistar品系大鼠直到24小时剥夺后才出现摄入量增加。结果显示了对乙醇反应的刺激控制，并证明了该程序在使乙醇反应在实验者选择的时间发生方面的适用性。
