Shorter Joanne H, Nelson David D, Barry McManus J, Zahniser Mark S, Milton Donald K
Aerodyne Research, Inc., Billerica, MA 01821 USA (
IEEE Sens J. 2009 Dec 11;10(1):76-84. doi: 10.1109/JSEN.2009.2035764.
Breath analysis is a powerful noninvasive technique for the diagnosis and monitoring of respiratory diseases, including asthma and chronic obstructive pulmonary disease (COPD). Nitric oxide (NO) and carbon monoxide (CO) are markers of airway inflammation and can indicate the extent of respiratory diseases. We have developed a compact fast response laser system for analysis of multiple gases by infrared absorption. The instrument uses room temperature quantum cascade lasers to simultaneously measure NO, CO, carbon dioxide (CO(2)) and nitrous oxide (N(2)O) in exhaled breath. Four breath flow rates are employed to explore their exchange dynamics in the lungs and airways. We obtain 1-s detection precisions of 0.5-0.8 parts-per-billion (ppb) for NO, CO, and N(2)O with an instrument response time of less than 1 s. The breath analysis system has been demonstrated in a preliminary study of volunteers. It is currently deployed in a trial clinical study.
呼吸分析是一种用于诊断和监测包括哮喘和慢性阻塞性肺疾病（COPD）在内的呼吸系统疾病的强大非侵入性技术。一氧化氮（NO）和一氧化碳（CO）是气道炎症的标志物，可指示呼吸系统疾病的严重程度。我们开发了一种紧凑的快速响应激光系统，用于通过红外吸收分析多种气体。该仪器使用室温量子级联激光器同时测量呼出气体中的NO、CO、二氧化碳（CO₂）和一氧化二氮（N₂O）。采用四种呼吸流速来探索它们在肺部和气道中的交换动力学。我们获得了NO、CO和N₂O的1秒检测精度为0.5-0.8十亿分之一（ppb），仪器响应时间小于1秒。该呼吸分析系统已在志愿者的初步研究中得到验证。目前它正在一项临床试验研究中使用。
