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体外膜肺氧合回路作为桥接手段抢救重症患者严重上肢再植

Use of an extracorporeal membrane oxygenation circuit as a bridge to salvage a major upper-extremity replant in a critically ill patient.

机构信息

Division of Plastic Surgery, Department of Surgery, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, New York, New York 10461, USA.

出版信息

J Reconstr Microsurg. 2010 Oct;26(8):517-22. doi: 10.1055/s-0030-1262951. Epub 2010 Aug 9.

Abstract

Major replantation of the upper extremity is defined as replantation at or above the level of the wrist. Selection of appropriate candidates is complex and requires consideration of many patient- and injury-associated factors including patient age, associated injuries, patient desire, mechanism of injury, ischemia time, wound condition, and presence of multiple-level injury. With respect to age, younger patients, especially children, are deemed to have a distinct advantage over more elderly patients due to improved nerve regeneration, and many advocate making every effort to replant this population. The risks of major upper-extremity replantation are significant and include bleeding, depletion of coagulation factors, secondary infection, and sepsis. As a result, major systemic illness and significant associated injuries are accepted as contraindications to limb salvage in this patient population. Herein we describe the use of an extracorporeal membrane oxygenation (ECMO) circuit as a potential bridge for short-term preservation of the extremity in a young patient with an acute, concomitant systemic illness. In the authors' opinion, use of ECMO perfusion is a viable means of maintaining extremity perfusion over hours or even days and may lead to broadened replant criteria in patients with associated injuries.

摘要

主要的上肢再植是指在腕关节或腕关节以上进行的再植。选择合适的候选人是复杂的,需要考虑许多与患者和损伤相关的因素,包括患者年龄、相关损伤、患者意愿、损伤机制、缺血时间、伤口状况和多水平损伤的存在。就年龄而言,年轻患者,尤其是儿童,由于神经再生改善,被认为比老年患者具有明显优势,许多人主张尽一切努力为这一人群进行再植。主要上肢再植的风险很大,包括出血、凝血因子耗竭、继发感染和败血症。因此,全身性疾病和严重的相关损伤被认为是该患者群体肢体保全的禁忌症。在此,我们描述了在一名患有急性合并全身性疾病的年轻患者中,使用体外膜氧合 (ECMO) 回路作为肢体短期保存的潜在桥梁。作者认为,使用 ECMO 灌注是维持肢体灌注数小时甚至数天的可行方法,并且可能导致伴有相关损伤的患者扩大再植标准。

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