Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China.
Org Lett. 2010 Sep 3;12(17):3918-21. doi: 10.1021/ol101607z.
Catalyzed by FeCl(3) under very mild conditions, tertiary enamides underwent a highly efficient intramolecular enaminic addition reaction to the ketonic carbonyls followed by 1,3-hydroxy rearrangement to produce 5-hydroxy-1H-pyrrol-2(5H)-ones in excellent yields.
在非常温和的条件下，三取代烯胺在三氯化铁的催化作用下，经历了高效的分子内烯胺加成反应，接着发生 1,3-羟基重排，以极好的收率生成 5-羟基-1H-吡咯-2(5H)-酮。
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