Mason Jessica M, Rees Gareth Jg
Bristol Haematology and Oncology Centre, Horfield Road, Bristol, BS2 8ED, UK.
J Oncol Pharm Pract. 2011 Dec;17(4):433-5. doi: 10.1177/1078155210381287. Epub 2010 Aug 10.
We describe a patient who experienced immediate onset severe thrombocytopenia as part of a hypersensitivity reaction to oxaliplatin, following substantial relatively uncomplicated previous exposure to the drug. We review other reports of acute hematological toxicity from oxaliplatin. We draw attention to the important need for vigilance when patients develop unusual acute symptoms during or shortly after oxaliplatin infusion.
