Wick M R
Washington University School of Medicine, St. Louis, Missouri.
Curr Opin Oncol. 1991 Apr;3(2):377-83. doi: 10.1097/00001622-199104000-00021.
Kaposi's sarcoma has achieved considerable notoriety in the past decade because of its association with the acquired immunodeficiency syndrome (AIDS). Nonetheless, this neoplasm continues to affect patients who do not have AIDS, and analysis of such cases may provide information that is useful in understanding the pathogenesis and treatment of Kaposi's sarcoma. Recent data indicate that non-AIDS-related Kaposi's sarcoma shows a predilection for individuals with the HLA-DR5 haplotype and that this genetic locus may affect immune function. In addition, other information suggests that infection with cytomegalovirus may represent the "trigger" for oncogenesis in patients with Kaposi's sarcoma. In view of the latter finding, therapies with such antiviral agents as zidovudine may be indicated in cases of non-AIDS-related Kaposi's sarcoma.
在过去十年中，卡波西肉瘤因其与获得性免疫缺陷综合征（艾滋病）的关联而声名远扬。尽管如此，这种肿瘤仍会影响非艾滋病患者，对这类病例的分析可能会提供有助于理解卡波西肉瘤发病机制和治疗方法的信息。最近的数据表明，非艾滋病相关的卡波西肉瘤在具有 HLA - DR5 单倍型的个体中更为常见，并且这个基因位点可能会影响免疫功能。此外，其他信息表明，巨细胞病毒感染可能是卡波西肉瘤患者肿瘤发生的“触发因素”。鉴于后一项发现，对于非艾滋病相关的卡波西肉瘤病例，可能需要使用齐多夫定等抗病毒药物进行治疗。
