糖尿病与代谢综合征中的胃饥饿素
Ghrelin in diabetes and metabolic syndrome.
作者信息
Pulkkinen Leena, Ukkola Olavi, Kolehmainen Marjukka, Uusitupa Matti
机构信息
Department of Clinical Nutrition, Food and Health Research Centre, University of Eastern Finland, Kuopio Campus, Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Campus P.O. Box 1627 FI-70211 Kuopio, Finland.
出版信息
Int J Pept. 2010;2010. doi: 10.1155/2010/248948. Epub 2010 Apr 27.
Abstract
Metabolic syndrome is a cluster of related risk factors for cardiovascular disease, type 2 diabetes and liver disease. Obesity, which has become a global public health problem, is one of the major risk factors for development of metabolic syndrome and type 2 diabetes. Obesity is a complex disease, caused by the interplay between environmental and genetic factors. Ghrelin is one of the circulating peptides, which stimulates appetite and regulates energy balance, and thus is one of the candidate genes for obesity and T2DM. During the last years both basic research and genetic association studies have revealed association between the ghrelin gene and obesity, metabolic syndrome or type 2 diabetes.
摘要
代谢综合征是一系列与心血管疾病、2型糖尿病和肝病相关的危险因素。肥胖已成为一个全球公共卫生问题，是代谢综合征和2型糖尿病发生的主要危险因素之一。肥胖是一种复杂的疾病，由环境和遗传因素相互作用引起。胃饥饿素是一种循环肽，可刺激食欲并调节能量平衡，因此是肥胖症和2型糖尿病的候选基因之一。在过去几年中，基础研究和基因关联研究均揭示了胃饥饿素基因与肥胖、代谢综合征或2型糖尿病之间的关联。
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