Mijaljica Dalibor, Prescott Mark, Devenish Rodney J
Methods Mol Biol. 2010;648:79-92. doi: 10.1007/978-1-60761-756-3_5.
Autophagy is a cellular quality control process by which cytoplasmic constituents including proteins, protein aggregates, organelles, and invading pathogens can be delivered to lysosomes for degradation. Autophagy is activated in response to changes in the internal status of the cell and/or changes in the extracellular environment. It is therefore essential for the maintenance of cellular homeostasis and for an efficient response to cellular stresses. As such autophagy has been implicated either in the pathogenesis, or response to a wide variety of diseases, bacterial, and viral infections, and ageing.
自噬是一种细胞质量控制过程，通过该过程，包括蛋白质、蛋白质聚集体、细胞器和入侵病原体在内的细胞质成分可被输送到溶酶体进行降解。自噬会因细胞内部状态的变化和/或细胞外环境的变化而被激活。因此，它对于维持细胞内稳态以及对细胞应激做出有效反应至关重要。正因如此，自噬与多种疾病、细菌和病毒感染以及衰老的发病机制或反应都有关联。
