deGast G C, Beatty P G, Amos D, Mickelson E M, Sullivan K M, Anderson J E, Giblett E R, Appelbaum F, Storb R, Deeg H J
Fred Hutchinson Cancer Research Center, Washington 98104.
Bone Marrow Transplant. 1991 Apr;7(4):293-5.
The effect of random red cell transfusions given shortly before allogeneic bone marrow transplantation (BMT) was evaluated in 969 leukemic patients transplanted from an HLA-identical sibling donor. Patients were divided into two groups: 501 who received a transfusion shortly before BMT, and 468 who did not. Both groups had a similar incidence of acute graft-versus-host disease (GVHD), but the recently-transfused group had a significantly lower incidence of chronic GVHD (35.9% vs 48.9%). These differences remained significant in a multivariate analysis of time to chronic GVHD (p = 0.022), taking into account other differences between the two groups and known risk factors for chronic GVHD.
对969例接受来自 HLA 相同同胞供者的异基因骨髓移植（BMT）的白血病患者，评估了在BMT前不久进行随机红细胞输注的效果。患者被分为两组：501例在BMT前不久接受了输血，468例未接受输血。两组急性移植物抗宿主病（GVHD）的发生率相似，但近期输血组慢性GVHD的发生率显著较低（35.9%对48.9%）。在对慢性GVHD发生时间的多变量分析中，考虑到两组之间的其他差异以及慢性GVHD的已知危险因素后，这些差异仍然显著（p = 0.022）。
