Health & Human Sciences, Southern Cross University, Lismore, Australia, and Centre for Health Promotion and Research, Sydney, NSW, Australia.
Obes Rev. 2011 May;12(5):339-45. doi: 10.1111/j.1467-789X.2010.00795.x.
A form of low-grade, systemic inflammation ('metaflammation') is linked to many types of chronic disease. Initially, this was thought to be causally related to weight gain and obesity and a possible explanation of the link between obesity and disease. However, several lifestyle-related inducers of such inflammation, some of which are associated with obesity, but some of which are not, have now been identified. The most common of these have been nutritive related, suggesting that there could still be a relationship, either directly or indirectly, with obesity. Here we provide evidence for non-nutritive inflammatory inducers, providing further support for an earlier suggestion that while obesity, beyond a point, may have a direct link with disease, this may be neither necessary nor sufficient to explain the current epidemic of chronic disease. A more ubiquitous cause encompassing all inflammatory inducers is the modern, post-industrial environment and lifestyles emanating from this. Obesity may thus be more of 'a canary in the mineshaft', warning of bigger global problems, than just a single pathway to modern environmentally driven disease.
低度全身性炎症（“代谢炎症”）与许多类型的慢性疾病有关。最初，人们认为这种炎症与体重增加和肥胖有关，可能是肥胖与疾病之间关联的一种解释。然而，现在已经确定了几种与这种炎症相关的生活方式诱导因素，其中一些与肥胖有关，而另一些则无关。这些最常见的与营养有关，这表明仍然可能存在直接或间接的与肥胖相关的关系。在这里，我们提供了非营养性炎症诱导物的证据，进一步支持了早先的观点，即尽管肥胖超过一定程度可能与疾病有直接联系，但这既不是必要条件，也不是充分条件来解释当前慢性疾病的流行。一个更普遍的、包含所有炎症诱导物的原因是现代后工业环境和由此产生的生活方式。因此，肥胖可能更多的是“矿井中的金丝雀”，它警告着更大的全球性问题，而不仅仅是通往现代环境驱动疾病的单一途径。
