Department of Life, Health and Environmental Sciences, University of L'Aquila, 67100 L'Aquila, Italy.
Sbarro Institute for Cancer Research and Molecular Medicine and Center for Biotechnology, Temple University, Philadelphia, PA 19122, USA.
Int J Mol Sci. 2019 Oct 31;20(21):5422. doi: 10.3390/ijms20215422.
Peroxisome proliferator-activated receptors (PPARs) are nuclear receptors that exert important functions in mediating the pleiotropic effects of diverse exogenous factors such as physical exercise and food components. Particularly, PPARs act as transcription factors that control the expression of genes implicated in lipid and glucose metabolism, and cellular proliferation and differentiation. In this review, we aim to summarize the recent advancements reported on the effects of lifestyle and food habits on PPAR transcriptional activity in chronic disease.
过氧化物酶体增殖物激活受体 (PPARs) 是核受体，在外源因素（如运动和食物成分）的多效性作用中发挥重要作用。特别是，PPAR 作为转录因子，控制参与脂质和葡萄糖代谢以及细胞增殖和分化的基因的表达。在这篇综述中，我们旨在总结关于生活方式和饮食习惯对慢性疾病中 PPAR 转录活性影响的最新进展。
