[Influence of chemical carcinogens on the physiological effects of adrenomimetics].

The experiments on isolated atria of rats and guinea pigs have shown that chemical hepatotropic carcinogens (diethylnitrosoamine and 2-acetyl aminofluorene) modify the physiological effects of adrenomimetics. A correlation between the authors' findings and the literature data on application of adrenergic drugs in carcinogenesis allows a suggestion to be made on the possibility of a principally new aspect in the mechanism of action of chemical carcinogens related to their effect on adrenoreceptors of target-organs.