文拉法辛具有抗抑郁样作用，该作用可被 μ-阿片受体基因敲除小鼠所消除。
Antidepressant-like effect of venlafaxine is abolished in μ-opioid receptor-knockout mice.
机构信息
Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Hokkaido University, Japan.
出版信息
J Pharmacol Sci. 2010;114(1):107-10. doi: 10.1254/jphs.10136sc. Epub 2010 Aug 10.
Abstract
Although the opioid system is known to modulate depression-like behaviors, its role in the effects of antidepressants is not yet clear. We investigated the role of μ-opioid receptors (MOPs) in the effects of venlafaxine, a serotonin and norepinephrine reuptake inhibitor, in the forced swim test using MOP-knockout (KO) mice. Venlafaxine reduced immobility time in wild-type mice (C57BL/6J), but not in MOP-KO mice, although no significant effects were observed on locomotor activity. These results suggest that MOPs play an important role in the antidepressant-like effects of venlafaxine.
摘要
尽管阿片系统被认为可以调节抑郁样行为，但它在抗抑郁药作用中的作用尚不清楚。我们使用μ-阿片受体（MOP）敲除（KO）小鼠研究了文拉法辛（一种 5-羟色胺和去甲肾上腺素再摄取抑制剂）对强迫游泳试验的影响。文拉法辛可减少野生型（C57BL/6J）小鼠的不动时间，但对 MOP-KO 小鼠则没有，尽管对运动活性没有观察到显著影响。这些结果表明 MOP 在文拉法辛的抗抑郁样作用中发挥重要作用。
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