Shanghai Key Laboratory of Compound Chinese Medicines, The Ministry of Education (MOE) Key Laboratory for Standardization of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham, Birmingham, AL, USA.
Prog Neuropsychopharmacol Biol Psychiatry. 2021 Jan 10;104:110041. doi: 10.1016/j.pnpbp.2020.110041. Epub 2020 Jul 16.
Depression is the most common psychiatric illness affecting numerous people world-wide. The currently available antidepressant treatment presents low response and remission rates. Thus, new effective antidepressants need to be developed or discovered. Aiming to give an overview of novel possible antidepressant drug targets, we summarized the molecular targets of antidepressants and the underlying neurobiology of depression. We have also addressed the multidimensional perspectives on the progress in the psychopharmacological treatment of depression and on the new potential approaches with effective drug discovery.
抑郁症是影响全球众多人群的最常见精神疾病。目前可用的抗抑郁治疗方法反应率和缓解率都较低。因此，需要开发或发现新的有效抗抑郁药。为了概述新的可能的抗抑郁药物靶点，我们总结了抗抑郁药的分子靶点和抑郁症的神经生物学基础。我们还讨论了抗抑郁症的精神药理学治疗进展和具有有效药物发现的新的潜在方法的多维视角。
