Zentrum für Molekulare Biologie der Universität Heidelberg (ZMBH), DKFZ-ZMBH-Allianz, Heidelberg, Germany.
Mol Cell. 2010 Aug 13;39(3):321-31. doi: 10.1016/j.molcel.2010.07.012.
Molecular chaperones assist folding processes and conformational changes in many proteins. In order to do so, they progress through complex conformational cycles themselves. In this review, I discuss the diverse conformational dynamics of the ATP-dependent chaperones of the Hsp60, Hsp70, Hsp90, and Hsp100 families.
分子伴侣协助许多蛋白质的折叠过程和构象变化。为了做到这一点，它们本身会经历复杂的构象循环。在这篇综述中，我讨论了 HSP60、HSP70、HSP90 和 HSP100 家族中依赖 ATP 的伴侣的不同构象动力学。
