Okabayashi S, Uchida K, Nakayama H, Ohno C, Hanari K, Goto I, Yasutomi Y
Corporation for Production and Research of Laboratory Primates, Hachimandai 1-1, Tsukuba-shi, Ibaraki 305-0843, Japan.
J Comp Pathol. 2011 Feb-Apr;144(2-3):204-11. doi: 10.1016/j.jcpa.2010.06.006. Epub 2010 Aug 12.
Periventricular leucomalacia (PVL) is a lesion of immature cerebral white matter that occurs in the perinatal period. In man, PVL is the predominant form of brain injury and a cause of cerebral palsy and cognitive deficits in premature infants. PVL affects fetuses and newborns, particularly those who have undergone oxygen deprivation as may occur in premature birth. Many clinical and pathological studies of PVL have been performed in man, but there is no clear definition of PVL in animals. A few spontaneous PVL-like cases in puppies or experimental cases in other animal species have been reported. The present study reports the histopathological and immunohistochemical features of PVL-like lesions in two neonatal cynomolgus monkeys. In both cases, there was cerebral white matter necrosis with marked infiltration of lipid-laden phagocytes and a reduction of neurons in the cerebral cortex. In case 1 there was extensive cavitation of the cerebral white matter. In case 2 there was reactive astrocytosis associated with a decrease in oligodendroglial cells and a decrease in cerebral white matter myelin. To our knowledge, this is the first report of PVL-like leucoencephalomalacia in non-human primates.
脑室周围白质软化（PVL）是一种发生在围产期的未成熟脑白质病变。在人类中，PVL是脑损伤的主要形式，也是早产儿脑瘫和认知缺陷的一个原因。PVL影响胎儿和新生儿，尤其是那些经历过如早产时可能发生的缺氧情况的婴儿。人类已经对PVL进行了许多临床和病理研究，但在动物中尚无PVL的明确定义。已经报道了小狗中的一些自发性PVL样病例或其他动物物种中的实验性病例。本研究报告了两只新生食蟹猴中PVL样病变的组织病理学和免疫组化特征。在这两个病例中，均存在脑白质坏死，伴有大量富含脂质的吞噬细胞浸润以及大脑皮质神经元减少。病例1中脑白质有广泛的空洞形成。病例2中存在反应性星形细胞增生，伴有少突胶质细胞减少和脑白质髓鞘减少。据我们所知，这是非人类灵长类动物中PVL样白质软化的首次报告。
