N-取代氨甲酰基-1,3-二恶烷的合成及其作为 VLA-4 拮抗剂的生物活性。
Synthesis and biological activity of N-substituted aminocarbonyl-1,3-dioxolanes as VLA-4 antagonists.
机构信息
Department of Medicinal Chemistry, New Drug Discovery Research, Ranbaxy Research Laboratories, Plot 20, Sector 18, Gurgaon 122015, Haryana, India.
出版信息
Bioorg Med Chem Lett. 2010 Sep 15;20(18):5514-20. doi: 10.1016/j.bmcl.2010.07.069. Epub 2010 Jul 23.
PMID:20705461
Abstract
A novel set of compounds with a 1,3-dioxolane ring which acts as a proline bioisostere have been successfully designed as VLA-4 receptor antagonists. Compounds (18e), (28j), and (35g) were shown to have high receptor affinities.
摘要
一组新型的以 1,3-二氧戊环为脯氨酸生物等排体的化合物已被成功设计为 VLA-4 受体拮抗剂。化合物 (18e)、(28j) 和 (35g) 显示出高受体亲和力。
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