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[脊髓损伤患者:精液质量与辅助生殖技术管理]

[The spinal cord injured patient: semen quality and management by Assisted Reproductive Technology].

作者信息

Perrin J, Saïas-Magnan J, Thiry-Escudié I, Gamerre M, Serment G, Grillo J-M, Guillemain C, Karsenty G

机构信息

CECOS, laboratoire de biologie de la reproduction, hôpital La Conception, AP-HM, 147, boulevard Baille, 13005 Marseille, France.

出版信息

Gynecol Obstet Fertil. 2010 Sep;38(9):532-5. doi: 10.1016/j.gyobfe.2010.07.007. Epub 2010 Aug 11.

Abstract

Men with spinal cord injury present a unique infertile population. Only 10 % of them can father children without medical assistance, owing to potential impairments in erection, ejaculation and semen quality. The algorithm typically followed is to retrieve semen by Penile Vibratory Stimulation, in case of failure by Electro Ejaculation. Most of these patients have normal sperm concentrations but abnormally low sperm motility and vitality in the ejaculate. The reasons for poor semen quality in spinal cord injured men are reviewed. If semen cannot be obtained by Electro Ejaculation, or if the ejaculate from Penile Vibratory Stimulation or Electro Ejaculation contains an insufficient quantity or quality of sperm for in vitro fertilization with intracytoplasmic sperm injection, then retrieval of sperm from reproductive tissues is attempted. Despite abnormal semen quality, successful pregnancies with sperm from spinal cord injured male partners have occurred by intravaginal insemination, intrauterine insemination, and in vitro fertilization with intracytoplasmic sperm injection. The prevailing pregnancy and fecundity rates in couples with a spinal cord injured male partner are reviewed.

摘要

脊髓损伤男性是一类特殊的不育群体。由于勃起、射精及精液质量方面可能存在的损害,其中只有10%的人能够在无医疗辅助的情况下使配偶受孕。通常采用的方法是通过阴茎震动刺激采集精液,若失败则采用电刺激射精。这些患者大多精子浓度正常,但射精时精子活力和生命力异常低下。本文对脊髓损伤男性精液质量差的原因进行了综述。如果电刺激射精无法获取精液,或者阴茎震动刺激或电刺激射精所获精液中精子数量或质量不足以用于卵胞浆内单精子注射体外受精,则尝试从生殖组织中获取精子。尽管精液质量异常,但通过阴道内授精、子宫内授精以及卵胞浆内单精子注射体外受精,脊髓损伤男性配偶仍成功受孕。本文还综述了男性脊髓损伤夫妇的妊娠率和生育力情况。

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