Dogra N, Puri G D, Rana S S
Advanced Cardiac Centre, Department of Anaesthesiology and Critical Care, PGIMER, Chandigarh, India.
Perfusion. 2010 Nov;25(6):417-21. doi: 10.1177/0267659110380770. Epub 2010 Aug 12.
Cardiac surgery involving cardiopulmonary bypass (CPB) in its conventional form involves many processes leading to free radical production, such as perioperative ischemia, reperfusion, circulation of whole body blood through the CPB circuit, hypothermia and acidosis. The red blood cells of a glucose-6-phosphate dehydrogenase (G6PD)-deficient person are unable to scavenge these free radicals, resulting in haemolysis. Here, we describe the successful anaesthetic management of two G6PD-deficient children who underwent cardiac surgery, on and off CPB, without any obvious haemolytic reaction, followed by a discussion of the disorder, with specific consideration of perioperative management of such cases.
传统形式的涉及体外循环（CPB）的心脏手术包含许多导致自由基产生的过程，如围手术期缺血、再灌注、全身血液通过体外循环回路循环、体温过低和酸中毒。葡萄糖-6-磷酸脱氢酶（G6PD）缺乏者的红细胞无法清除这些自由基，从而导致溶血。在此，我们描述了两名接受心脏手术的G6PD缺乏儿童在体外循环期间及非体外循环期间成功的麻醉管理，未出现任何明显的溶血反应，随后对该病症进行了讨论，并特别考虑了此类病例的围手术期管理。
