致畸学原理：它们仍然正确吗？
The principles of teratology: are they still true?
作者信息
Friedman Jan M
机构信息
Department of Medical Genetics, University of British Columbia, and Child & Family Research Institute, Children’s & Women’s Hospital, 4500 Oak Street, Vancouver, BC, Canada.
出版信息
Birth Defects Res A Clin Mol Teratol. 2010 Oct;88(10):766-8. doi: 10.1002/bdra.20697.
James Wilson originally proposed a set of "Principles of Teratology" in 1959, the year before he helped to found the Teratology Society. By 1977, when these Principles were presented in a more definitive form in Wilson and Fraser's Handbook of Teratology, they had become a standard formulation of the basic tenets of the field. Wilson's Principles have continued to guide scientific research in teratology, and they are widely used in teaching. Recent advances in our knowledge of the molecular and cellular bases of embryogenesis serve only to provide a deeper understanding of the fundamental developmental mechanisms that underlie Wilson's Principles of Teratology.
1959年，詹姆斯·威尔逊首次提出了一套“致畸学原理”，就在前一年，他协助创立了致畸学协会。到1977年，当这些原理以更权威的形式出现在威尔逊和弗雷泽所著的《致畸学手册》中时，它们已成为该领域基本信条的标准表述。威尔逊的原理一直指导着致畸学的科学研究，并且在教学中广泛应用。我们在胚胎发生的分子和细胞基础方面知识的最新进展，只是为了更深入地理解作为威尔逊致畸学原理基础的基本发育机制。
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