Department of Surgical Sciences, Advanced Tecnology and Organ Transplant, Policlinico, Cannizzaro Hospital, University of Catania, Catania, Italy.
Eur Rev Med Pharmacol Sci. 2010 Aug;14(8):727-30.
Gastrointestinal Stromal Tumor (GIST) is a rare intra-abdominal tumor, characterized by a specific histological and immunohistochemical pattern. These tumors affect with higher frequency stomach and small bowel and occur at a median age of 60 years with a slight male predominance. An early stage of GIST often don't cause any symptoms, so most GISTs are diagnosed in later stages of the disease. We report a case of GIST diagnosed only with clinical data and positron emission tomography (PET). We demonstrate the usefulness of neoadjuvant treatment with Imatinib mesylate, a newly developed tyrosine kinase receptor inhibitor. The neoadjuvant treatment with Imatinib reduced the mass size and vascularization, making possible a surgical approach.
胃肠道间质瘤（GIST）是一种罕见的腹腔内肿瘤，具有特定的组织学和免疫组织化学特征。这些肿瘤主要影响胃和小肠，中位发病年龄为 60 岁，男性略多见。GIST 的早期阶段通常不会引起任何症状，因此大多数 GIST 是在疾病的晚期诊断出来的。我们报告了一例仅通过临床资料和正电子发射断层扫描（PET）诊断的 GIST 病例。我们展示了新开发的酪氨酸激酶受体抑制剂甲磺酸伊马替尼的新辅助治疗的有用性。伊马替尼的新辅助治疗降低了肿瘤的大小和血管生成，使得手术成为可能。
