Krzyściak Paweł, Macura Anna B
Department of Mycology, Chair of Microbiology, Jagiellonian University Collegium Medicum, 18 Czysta Street, 31-121 Cracow, Poland.
Wiad Parazytol. 2010;56(2):167-70.
Rhodotorula sp. have emerged as opportunistic pathogens, particularly in immunocompromised patients. Knowledge about the susceptibility of Rhodotorula strains to the common antifungal drugs is essential for the treatment of such new infections. The 68 isolates identified as: Rhodotorula mucilaginosa (47 strains; 69%), R. minuta (14; 21%) and R. glutinis (7; 10%) obtained from various sources (feces, skin and nails, vagina and hospital environment) were tested for susceptibility to 5-fluorocytosine (5FC), amphotericin B (AMB), fluconazole (FLC) and itraconazole (ITR). All of the isolates had low MICs for AMB and 5FC. For ITR, the R. minuta isolates had the lowest MICs within a range 0.125-0.25 mg/l and for FLC all isolates affected within the range 2-64 mg/l. The majority of R. mucilaginosa isolates (82.2%) had MICs in the range 64-128 mg/l for FLC and 95.6% of isolates had MICs above or equal to 2 mg/1 for ITR.
红酵母已成为机会致病菌，尤其是在免疫功能低下的患者中。了解红酵母菌株对常见抗真菌药物的敏感性对于治疗此类新感染至关重要。从不同来源（粪便、皮肤和指甲、阴道及医院环境）获得的68株鉴定为粘红酵母（47株；69%）、微小红酵母（14株；21%）和酿酒酵母（7株；10%）的菌株，检测了它们对5-氟胞嘧啶（5FC）、两性霉素B（AMB）、氟康唑（FLC）和伊曲康唑（ITR）的敏感性。所有分离株对AMB和5FC的最低抑菌浓度（MIC）都很低。对于ITR，微小红酵母分离株的MIC最低，范围在0.125-0.25mg/l，对于FLC，所有分离株的MIC在2-64mg/l范围内。大多数粘红酵母分离株（82.2%）对FLC的MIC在64-128mg/l范围内，95.6%的分离株对ITR的MIC高于或等于2mg/1。
