Camera L, Del Vecchio S, Petrillo A, Esposito G, Frasci G, Iaffaioli R V, Bianco A R, Salvatore M
Nuclear Medicine Department, National Cancer Institute, Naples, Italy.
Eur J Nucl Med. 1991;18(4):269-73. doi: 10.1007/BF00186652.
We used radiolabelled monoclonal antibodies (MoAbs) to prove disease persistence after treatment for ovarian carcinoma. Twelve patients with histologically confirmed ovarian carcinoma were studied. They received 5 mCi (1 mg) of iodine-131-B72.3 by intravenous injection before and after a complete course of chemotherapy. Images were obtained with a LFOV gamma camera 2 h after MoAb administration and daily up to 6 days. Before treatment 8 patients had a true positive scan. Questionable antibody uptake was observed in 2 patients while 1 had a true negative scan and 1 a false-negative examination. After treatment the therapeutic response was evaluated. Five patients had partial remission and antibody scan showed persistence of disease in all patients except 1. Four patients showed progression of the disease and 1 no change. The antibody scan was positive in 4 and questionable in 1. Two patients had complete remission and negative antibody scans. Computed tomography (CT) could not always discriminate postoperative fibrosis from tumour lesions, especially when the peritoneum was involved in the disease. High serum levels of tumour markers were constantly associated with the presence of tumour lesions, but normal values did not guarantee absence of disease. We conclude than the antibody scan is complementary to CT and serum tumor markers in the definition of therapeutic response.
我们使用放射性标记的单克隆抗体（MoAbs）来证实卵巢癌治疗后疾病的持续存在。对12例经组织学确诊为卵巢癌的患者进行了研究。他们在完成一个完整的化疗疗程前后，通过静脉注射接受了5毫居里（1毫克）的碘-131-B72.3。在给予单克隆抗体后2小时，使用大视野γ相机获取图像，并在之后6天内每天进行一次。治疗前，8例患者扫描结果为真阳性。2例患者观察到可疑的抗体摄取，1例患者扫描结果为真阴性，1例为假阴性检查。治疗后评估治疗反应。5例患者部分缓解，抗体扫描显示除1例患者外，所有患者疾病持续存在。4例患者疾病进展，1例无变化。抗体扫描4例为阳性，1例可疑。2例患者完全缓解，抗体扫描为阴性。计算机断层扫描（CT）并不总能区分术后纤维化与肿瘤病变，尤其是当疾病累及腹膜时。高血清肿瘤标志物水平常与肿瘤病变的存在相关，但正常数值并不能保证无疾病。我们得出结论，在确定治疗反应方面，抗体扫描是对CT和血清肿瘤标志物的补充。
