Qian H N, Feng J, Cui H, Gao B S, Qin S L, Fu T Y, Wei P, Fu Z Y, Gao S M, Yang Z Y
Gynecologic Oncology Research Laboratory, People's Hospital, Beijing Medical University.
Chin Med J (Engl). 1991 Feb;104(2):109-13.
Monoclonal antibody 131I-COC183B2, developed in our laboratory and proved to fit for human treatment was injected intraperitoneally or subcutaneously in 13 patients. In 8 cases with i.p. injection the disease corresponded with the image, i.e. 3 primary ovarian epithelial cancers showed positive images, 1 ovarian Krukenberg tumor was negative and the other 4 negative images included 1 uterine myoma and 3 ovarian teratomas. In the subcutaneous injection group, 4 cases had ovarian carcinoma, surgery and chemotherapy. Two negative images corresponded with the clinical status-in good health, another negative case had metastatic left supraclavicular lymph node due to ovarian mucinous adenocarcinoma. The last negative image in this group was a case of benign ovarian teratoma which was proved after surgery. The 1 positive case was waiting to be proved by a scheduled third operation. The computer scintigram calculation of T/NT was 5.35 to 13.7. The results suggest that this monoclonal antibody can be used for radioimmunoimaging for the localization of ovarian carcinoma, which is not only helpful for clinical staging and differential diagnosis but is also a good follow-up method.
在我们实验室研制并证明适用于人体治疗的单克隆抗体131I-COC183B2，对13例患者进行了腹腔内或皮下注射。在8例腹腔注射的病例中，疾病情况与影像相符，即3例原发性卵巢上皮癌显示阳性影像，1例卵巢库肯勃瘤为阴性，另外4例阴性影像包括1例子宫肌瘤和3例卵巢畸胎瘤。在皮下注射组中，4例患有卵巢癌，接受了手术和化疗。2例阴性影像与临床状况相符——身体健康，另1例阴性病例因卵巢黏液腺癌出现左锁骨上淋巴结转移。该组最后1例阴性影像为1例良性卵巢畸胎瘤，术后得以证实。1例阳性病例有待通过计划中的第三次手术予以证实。计算机闪烁图计算的T/NT为5.35至13.7。结果表明，这种单克隆抗体可用于卵巢癌定位的放射免疫显像，这不仅有助于临床分期和鉴别诊断，也是一种很好的随访方法。
