Department of Clinical Neurosciences, University of Calgary, Canada.
J Neurol Sci. 2010 Oct 15;297(1-2):76-81. doi: 10.1016/j.jns.2010.07.014. Epub 2010 Aug 12.
Abnormally decreased deep gray matter (GM) signal intensity on T2-weighted MRI (T2 hypointensity) is associated with brain atrophy and disability progression in patients with multiple sclerosis (MS) and is believed to represent excessive iron deposition. We investigated the time course of deep GM T2 hypointensity and its relationship with disability at 3T in 8 stable relapsing-remitting (RR) MS patients treated with minocycline over 3years. MRI and disability measurements were compared at baseline, 6, 12, 24, and 36months. Grand mean deep GM T2 hypointensity was negatively correlated with EDSS over time (r=-0.94, P=0.02). This correlation was strongest in the head of caudate (r=-0.95, P=0.01) and putamen (r=-0.89, P=0.04). Additionally, baseline grand mean deep GM T2 hypointensity appears to predict third year EDSS (r=-0.72, P=0.04). These results suggest that iron associated deep GM injury correlates with patient disability in stable RRMS. Measurements of deep GM T2 hypointensity at high field MRI may prove to be useful in monitoring individuals with MS. Further studies are required to confirm these results in a large sample and to determine if T2 hypointensity changes in clinically active MS patients.
磁共振成像（MRI）T2 加权像上深灰质（GM）信号强度异常降低（T2 低信号）与多发性硬化症（MS）患者的脑萎缩和残疾进展有关，被认为代表过量的铁沉积。我们在 8 例接受米诺环素治疗的稳定复发缓解型（RR）MS 患者中，在 3T 上研究了深部 GM T2 低信号的时间过程及其与残疾的关系。在基线、6、12、24 和 36 个月时比较 MRI 和残疾测量值。大脑深部 GM T2 低信号的平均强度与 EDSS 呈负相关（r=-0.94，P=0.02）。在尾状核头部（r=-0.95，P=0.01）和壳核（r=-0.89，P=0.04）的相关性最强。此外，基线深部 GM T2 低信号平均强度似乎可以预测第三年的 EDSS（r=-0.72，P=0.04）。这些结果表明，与铁相关的深部 GM 损伤与稳定 RRMS 患者的残疾相关。在高场 MRI 上测量深部 GM T2 低信号可能证明对监测 MS 个体有用。需要进一步的研究来在大样本中证实这些结果，并确定是否在临床上活跃的 MS 患者中 T2 低信号有变化。
