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由于角化过度导致的滤泡阻塞:对乳头瘘管发病机制的新假说。

Follicular occlusion due to hyperkeratosis: a new hypothesis on the pathogenesis of mammillary fistula.

机构信息

Department of Radiology, Virgen de la Arrixaca University Hospital, 30120-El Palmar (Murcia), Spain.

出版信息

Med Hypotheses. 2010 Dec;75(6):553-4. doi: 10.1016/j.mehy.2010.07.027. Epub 2010 Aug 12.

DOI:10.1016/j.mehy.2010.07.027
PMID:20708341
Abstract

Mammary fistula (MF) is a disease characterised by recurrent draining abscesses around the areola. The aetiology of MF remains unclear. The most common cause is duct obstruction by squamous metaplasia. The clinical aspects and histological findings of MF are very similar to those observed in hidradenitis suppurativa (HS). We propose a new hypothesis on the pathogenesis of MF and suggest that occlusion of hair follicles by keratinous plugging may relevantly contribute to the development of MF.

摘要

乳腺瘘管(MF)是一种以乳晕周围反复出现引流脓肿为特征的疾病。MF 的病因尚不清楚。最常见的原因是鳞状化生导致的导管阻塞。MF 的临床和组织学表现与化脓性汗腺炎(HS)非常相似。我们提出了一个关于 MF 发病机制的新假说,并认为角蛋白栓阻塞毛囊可能与 MF 的发生发展有关。

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Follicular occlusion due to hyperkeratosis: a new hypothesis on the pathogenesis of mammillary fistula.由于角化过度导致的滤泡阻塞:对乳头瘘管发病机制的新假说。
Med Hypotheses. 2010 Dec;75(6):553-4. doi: 10.1016/j.mehy.2010.07.027. Epub 2010 Aug 12.
2
Hidradenitis suppurativa (acne inversa): early inflammatory events at terminal follicles and at interfollicular epidermis.化脓性汗腺炎(反向痤疮):终末毛囊和毛囊间表皮的早期炎症事件。
Exp Dermatol. 2010 Jun;19(6):533-7. doi: 10.1111/j.1600-0625.2009.00915.x. Epub 2009 Jul 29.
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Mammary fistula could be included in the follicular occlusion tetrad.乳腺瘘可包含在毛囊闭锁三联征中。 (注:原文中“follicular occlusion tetrad”表述有误,正确的是“follicular occlusion triad”,即毛囊闭锁三联征,翻译时按照正确内容进行了翻译)
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Preliminary findings suggest hidradenitis suppurativa may be due to defective follicular support.初步研究结果表明,化脓性汗腺炎可能是由于毛囊支持缺陷所致。
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[Neviform hyperkeratosis of the mammary areola].[乳晕痣样角化过度症]
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