基于先天性心脏缺陷和心肌病的心力衰竭患儿中 BNP 和 NT-ProBNP 测量的诊断性能。

Diagnostic performance of BNP and NT-ProBNP measurements in children with heart failure based on congenital heart defects and cardiomyopathies.

机构信息

Pediatric Cardiology Department, Hacettepe University Medical School, Turkey.

出版信息

Clin Biochem. 2010 Nov;43(16-17):1278-81. doi: 10.1016/j.clinbiochem.2010.08.002. Epub 2010 Aug 13.

DOI:10.1016/j.clinbiochem.2010.08.002

PMID:20709045

Abstract

OBJECTIVES

To test the diagnostic performance of BNP and NT-ProBNP in children with different hemodynamic dysfunctions.

DESIGN AND METHODS

Seventy children who underwent echocardiography and were classified into left and right ventricle volume and pressure overload (LVvO, LVpO, RVvO, and RVpO, respectively) and biventricular volume overload (BVvO) were enrolled.

RESULTS

BNP and NT-ProBNP levels in all groups were higher than those in the control group (p<0.001, p<0.001). The increase in peptide levels was strongly correlated with the severity of heart failure (p<0.001, p<0.001). There was no significant difference in peptide levels in-between LVvO, LVpO, RVvO, RVpO and BVvO groups. Both measurements were significantly correlated (r=0.76, p<0.001) with each other. NT-ProBNP showed a high sensitivity, whereas BNP showed a high specificity and accuracy. AUCs in ROC-curve were 0.97 for BNP and 0.96 for NT-ProBNP.

CONCLUSIONS

NT-ProBNP may be used in screening of risk groups for cardiac failure because of its' higher sensitivity, but BNP may be specifically used in monitoring patients with heart failure.

摘要

目的

检测 BNP 和 NT-ProBNP 在不同血流动力学功能障碍患儿中的诊断性能。

设计和方法

共纳入 70 名接受超声心动图检查并分为左心室和右心室容量和压力超负荷（LVvO、LVpO、RVvO 和 RVpO，分别）和双心室容量超负荷（BVvO）的患儿。

结果

所有组的 BNP 和 NT-ProBNP 水平均高于对照组（p<0.001，p<0.001）。肽水平的升高与心力衰竭的严重程度强烈相关（p<0.001，p<0.001）。LVvO、LVpO、RVvO、RVpO 和 BVvO 组之间肽水平无显著差异。两种测量结果均呈显著相关性（r=0.76，p<0.001）。NT-ProBNP 具有较高的敏感性，而 BNP 具有较高的特异性和准确性。ROC 曲线下的 AUC 为 BNP 的 0.97 和 NT-ProBNP 的 0.96。