Department of Surgery, National University of Singapore, Singapore, Singapore.
J Mol Cell Cardiol. 2011 Feb;50(2):312-9. doi: 10.1016/j.yjmcc.2010.08.009. Epub 2010 Aug 13.
Cell therapy and tissue engineering attract increasing attention as a potential approach for cardiac repair. Adult stem cells from autologous origin are a practically safe and appealing source for cell-based regenerative therapies that may hold realistic clinical potential. A plethora of interesting concepts have been introduced aiming at regenerating ischemic myocardium through adult stem cell-based bioartificial cardiac tissue supplements. Yet, current pre-clinical concepts have not reached translational applicability, and successes are only episodic. This review will provide a brief overview of the latest concepts and breakthroughs in the emerging field of cardiac adult stem cell-based tissue engineering, and discuses the challenges that this field needs to overcome to achieve realistic therapeutic translation into the clinical arena. This article is part of a special issue entitled, "Cardiovascular Stem Cells Revisited".
细胞治疗和组织工程作为一种潜在的心脏修复方法，越来越受到关注。自体来源的成体干细胞是一种实际安全且具有吸引力的细胞再生治疗来源，具有潜在的临床应用价值。为了通过基于成体干细胞的生物人工心脏组织补充来再生缺血性心肌，提出了大量有趣的概念。然而，目前的临床前概念尚未达到转化应用的程度，成功的案例也只是偶发的。这篇综述将简要概述心脏成体干细胞组织工程这一新兴领域的最新概念和突破，并讨论该领域需要克服的挑战，以实现真正的治疗转化到临床领域。本文是题为“心血管干细胞再探讨”的特刊的一部分。
