Department of Biology, Faculty of Science, Islamic Azad University, Science and Research Branch, Tehran 99999, Iran.
Behav Brain Res. 2011 Jan 1;216(1):270-4. doi: 10.1016/j.bbr.2010.08.003. Epub 2010 Aug 13.
Alzheimer's disease (AD) is a progressive neurodegenerative disease that is characterized by a decline in cognitive function and severe neuronal loss in the cerebral cortex and certain subcortical regions of the brain including nucleus basalis magnocellularis (NBM) that play an important role in learning and memory. There are few therapeutic regimens that influence the underlying pathogenic phenotypes of AD, however, of the currently available therapies, exercise training is considered to be one of the best strategies for attenuating the pathological phenotypes of AD for people with AD. Here, we sought to investigate the effect of treadmill running on spatial memory in Alzheimer-induced rats. Male Wistar rats were split into two groups namely shams (n=7) and lesions with the lesion group subdivided further into the lesion-rest (n=7) and lesion-exercise (n=7). The lesion-exercise and shams were subjected to treadmill running at 17 meters per minute (m/min) for 60 min per day (min/day), 7 days per week (days/wk), for 60 days. Spatial memory was investigated using the Morris Water Maze test in the rats after 60 days of Alzheimer induction and the exercise. Our data demonstrated that spatial memory was indeed impaired in the lesion group compared with the shams. However, exercise notably improved spatial memory in the lesion-exercised rats compared to lesion-rested group. The present results suggest that spatial memory is affected under Alzheimer conditions and that treadmill running improves these effects. Our data suggested that treadmill running contributes to the alleviation of the cognitive decline in AD.
阿尔茨海默病（AD）是一种进行性神经退行性疾病，其特征是认知功能下降和大脑皮层以及某些皮质下区域（包括基底核大细胞核）的严重神经元丧失，这些区域在学习和记忆中起着重要作用。目前很少有治疗方案可以影响 AD 的潜在发病表型，但是，在现有的治疗方法中，运动训练被认为是减轻 AD 患者 AD 病理表型的最佳策略之一。在这里，我们试图研究跑步机跑步对阿尔茨海默病诱导大鼠空间记忆的影响。雄性 Wistar 大鼠分为两组，即假手术组（n=7）和损伤组，损伤组进一步分为损伤休息组（n=7）和损伤运动组（n=7）。损伤运动组和假手术组以 17 米/分钟（m/min）的速度每天进行 60 分钟（min/day）、每周 7 天（days/wk）的跑步机跑步，共 60 天。在阿尔茨海默病诱导和运动 60 天后，使用 Morris 水迷宫测试对大鼠的空间记忆进行了研究。我们的数据表明，与假手术组相比，损伤组的空间记忆确实受损。然而，与损伤休息组相比，运动显著改善了损伤运动组的空间记忆。本研究结果表明，在阿尔茨海默病条件下，空间记忆受到影响，跑步机跑步可改善这种影响。我们的数据表明，跑步机跑步有助于减轻 AD 认知能力下降。
