Tsivyan P B, Vasenina A D
Laboratory of biophysics, Mother and Child Care Institute, Sverdlovsk, U.S.S.R.
Eur J Obstet Gynecol Reprod Biol. 1991 Jul 1;40(2):105-10. doi: 10.1016/0028-2243(91)90100-y.
To assess possible changes in myocardial contractile function and relaxation occurring after mild perinatal asphyxia, maximal blood pressure and M-mode echocardiograms were registered simultaneously in 32 normal full-term neonates and in 22 full-term asphyxiated neonates. The slope of the end-systolic pressure-dimension relation (ESPDR) was used as a reliable index for evaluation of myocardial contractility. A nonpharmacological afterload increase was performed to calculate this relation. The following most prominent changes were observed in asphyxiated neonates: slope of ESPDR 5.9 vs 14.4 mmHg/(cm/m2); normalized peak rate of left ventricular (LV) filling 2.14 vs. 4.11 s(-1); LV isovolumic relaxation period 63 vs 36 ms. These results suggest that ESPDR and parameters of LV relaxation and filling may serve as early and sensitive signs of hypoxic myocardial dysfunction.
为评估轻度围产期窒息后心肌收缩功能和舒张功能可能发生的变化，对32例正常足月新生儿和22例足月窒息新生儿同时记录了最大血压和M型超声心动图。收缩末期压力-维度关系（ESPDR）的斜率被用作评估心肌收缩力的可靠指标。通过非药物性增加后负荷来计算这种关系。在窒息新生儿中观察到以下最显著的变化：ESPDR斜率为5.9 vs 14.4 mmHg/(cm/m2)；左心室（LV）充盈标准化峰值速率为2.14 vs. 4.11 s(-1)；LV等容舒张期为63 vs 36 ms。这些结果表明，ESPDR以及LV舒张和充盈参数可能是缺氧性心肌功能障碍的早期敏感征象。
