Jaffredo Thierry, Richard Charlotte, Pouget Claire, Teillet Marie-Aimée, Bollérot Karine, Gautier Rodolphe, Drevon Cécile
CNRS and UPMC UMR7622, Laboratoire de Biologie du Développement, Paris, France.
Int J Dev Biol. 2010;54(6-7):1045-54. doi: 10.1387/ijdb.103062tj.
Since the era of the ancient Egyptians and Greeks, the avian embryo has been a subject of intense interest to visualize the first steps of development. It has served as a pioneer model to scrutinize the question of hematopoietic development from the beginning of the 20th century. It's large size and easy accessibility have permitted the development of techniques dedicated to following the origins and fates of different cell populations. Here, we shall review how the avian model has brought major contributions to our understanding of the development of the hematopoietic system in the past four decades and how these discoveries have influenced our knowledge of mammalian hematopoietic development. The discovery of an intra-embryonic source of hematopoietic cells and the developmental link between endothelial cells and hematopoietic cells will be presented. We shall then point to the pivotal role of the somite in the construction of the aorta and hematopoietic production and demonstrate how two somitic compartments cooperate to construct the definitive aorta. We shall finish by showing how fate-mapping experiments have allowed the identification of the tissue which gives rise to the sub-aortic mesenchyme. Taken together, this review aims to give an overview of how and to what extent the avian embryo has contributed to our knowledge of developmental hematopoiesis.
自古埃及人和希腊人时代起，禽类胚胎就一直是人们密切关注的对象，用于观察发育的最初步骤。从20世纪初开始，它就作为一个先驱模型来研究造血发育问题。其体积大且易于获取，使得专门用于追踪不同细胞群体起源和命运的技术得以发展。在此，我们将回顾在过去四十年中禽类模型如何为我们理解造血系统的发育做出了重大贡献，以及这些发现如何影响了我们对哺乳动物造血发育的认识。将介绍胚胎内造血细胞来源的发现以及内皮细胞与造血细胞之间的发育联系。然后，我们将指出体节在主动脉构建和造血产生中的关键作用，并展示两个体节区室如何协作构建定型主动脉。最后，我们将展示命运图谱实验如何使我们能够识别产生主动脉下间充质的组织。综上所述，本综述旨在概述禽类胚胎如何以及在多大程度上为我们对发育性造血的认识做出了贡献。
