Lepage Stephanie E, Bruce Ashley E E
Department of Cell and Systems Biology, University of Toronto, 25 Harbord Street, Toronto, Ontario, Canada.
Int J Dev Biol. 2010;54(8-9):1213-28. doi: 10.1387/ijdb.093028sl.
Gastrulation involves of a series of coordinated cell movements to organize the germ layers and establish the major body axes of the embryo. One gastrulation movement is epiboly, which involves the thinning and spreading of a multilayered cell sheet. Epiboly plays a prominent role in zebrafish gastrulation and studies of zebrafish epiboly have provided insights into basic cellular properties and mechanisms of morphogenesis that are widely used in animal development. Although considerable progress has been made in identifying molecules that are required for epiboly, we still understand very little about how these factors cooperate to drive the process. Here, we review work on the molecular and cellular basis of zebrafish epiboly in order to identify unifying themes and to highlight some of the current open questions.
原肠胚形成涉及一系列协调的细胞运动，以组织胚层并确立胚胎的主要体轴。其中一种原肠胚形成运动是外包，即多层细胞片变薄并扩展。外包在斑马鱼原肠胚形成过程中起着重要作用，对斑马鱼外包的研究为广泛应用于动物发育的基本细胞特性和形态发生机制提供了见解。尽管在确定外包所需分子方面已取得了相当大的进展，但我们对这些因子如何协同驱动这一过程仍知之甚少。在此，我们综述关于斑马鱼外包的分子和细胞基础的研究工作，以确定统一的主题并突出一些当前未解决的问题。
